QSAR of anticancer compounds. Bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides)

Authors
Mekapati, SB Denny, WA Kurup, A Hansch, C
Citation
Sb. Mekapati et al., QSAR of anticancer compounds. Bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides), BIO MED CH, 9(11), 2001, pp. 2757-2762
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
11
Year of publication
2001
Pages
2757 - 2762
Database
ISI
SICI code
0968-0896(200111)9:11<2757:QOACB>2.0.ZU;2-U
Abstract
QSAR have been developed for. the anticancer activity (growth inhibition) o f various tumor cells by bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamid es), bis(phenazine-1-carboxamides), and bis(naphthalimides). Of the seven Q SAR, positive hydrophobic interactions are found in only two examples: bis( naphthalimides) versus human colon cancer cells. This is consistent with ot her QSAR of anticancer compounds where hydrophobic interactions are found t o be unimportant. (C) 2001 Elsevier Science Ltd. All rights reserved.