Modified iridoid glycosides as anti-implantation agents: Inhibition of cell adhesion as an approach for developing pregnancy interceptive agents

Authors
Misra, AP Mathad, VT Raj, K Bhaduri, AP Tiwari, R Srivastava, A Mehrotra, PK
Citation
Ap. Misra et al., Modified iridoid glycosides as anti-implantation agents: Inhibition of cell adhesion as an approach for developing pregnancy interceptive agents, BIO MED CH, 9(11), 2001, pp. 2763-2772
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
11
Year of publication
2001
Pages
2763 - 2772
Database
ISI
SICI code
0968-0896(200111)9:11<2763:MIGAAA>2.0.ZU;2-I
Abstract
Structural modifications in iridoid glycosides and evaluation of their effi cacy on adhering capability (in vitro) of immature hamster uterine epitheli al cells to the substratum have been studied. Out of 31, eight compounds in vitro, five compounds in utero and two in vivo showed adhesion/implantatio n preventing activity, respectively. The results provide an indication for further exploration in the line of development of anti-adhesive agents. (C) 2001 Published by Elsevier Science Ltd.