N. Saeki et al., Long-term Karnofsky performance status and neurological outcome in patients with neurohypophyseal germinomas, BR J NEUROS, 15(5), 2001, pp. 402-408
Long-term posttreatment Karnofsky Performance Status (KPS) and neurological
status of 16 patients with neurohypophyseal (NH) germinomas were retrospec
tively analysed, in order to deduce the best treatment modality to achieve
a good outcome. The average age at treatment was 15.5 years (rouge 6-26) an
d they were followed up for 107.3 months (26-209). The KPS averaged 81.5 (0
-100). Three patients were below 60 in the KPS. The first one had hemipares
is due to a delayed cerebrovascular accident (CVA), and the second became i
ndifferent and inactive with recent memory loss. The third died from margin
al recurrence of tumour and subsequent systemic metastasis. The low scores
were all more or less attributable to complications related to irradiation:
delayed CVA, diffuse cortical atrophy and inappropriate selection of irrad
iation field, respectively. The second case had the tumour origin at the hy
pothalamus, which indicates intraparenchymal tumour location as another fac
tor to worsen the quality of life (QOL). Visual field and acuity, and EOM i
mpairment were observed in eight and five patients, respectively. It improv
ed in all patients but one. The visual and EOM dysfunction recovered satisf
actorily and was not a disabling factor. The intraparenchymal lesion result
ing in hemiparesis and higher cortical dysfunction due to either irradiatio
n-related complications or tumour invasion is a major determining factor of
lower KPS. Irradiation related complications are considered to be avoidabl
e by reducing radiation dosage with appropriate chemotherapy and/or proper
selection of irradiation field. Patients with smaller tumour size of less t
han 20 mm had higher KPS. Accordingly, repeated studies of tumour markers a
nd neuroimages are required in patients with idiopathic diabetes insipidis,
in order to detect the tumour, if present, at the small-sized and early st
age.