Chemical modification of chitosan. Part 9: Reaction of N-carboxyethylchitosan methyle with diamines of acetal ending PAMAM dendrimers

Authors
Sashiwa, H Shigemasa, Y Roy, R
Citation
H. Sashiwa et al., Chemical modification of chitosan. Part 9: Reaction of N-carboxyethylchitosan methyle with diamines of acetal ending PAMAM dendrimers, CARBOHY POL, 47(2), 2002, pp. 201-208
Citations number
17
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE POLYMERS
ISSN journal
01448617 → ACNP
Volume
47
Issue
2
Year of publication
2002
Pages
201 - 208
Database
ISI
SICI code
0144-8617(20020201)47:2<201:CMOCP9>2.0.ZU;2-Y
Abstract
N-carboxyethylchitosan methyl ester (degree of substitution (DS) = 1.2 per repeating residue of chitosan), which was prepared from chitosan and methyl acrylate by the Michael reaction, was reacted with diamine and gave a wate r-soluble product. The DS value of the diamine moiety was 0.64-0.94. Acetal ending poly(amidoamine) (PAMAM) dendrimers were successfully attached to t he ester and gave an N-carboxyethylchitosan-dendrimer hybrid without any cr osslinking. The DS values of the hybrids were gradually decreased from 0.61 to 0.04 with the increasing generation of dendrimer. (C) 2002 Elsevier Sci ence Ltd. All rights reserved.