Recent advances in solventless organic reactions: towards benign synthesiswith remarkable versatility

A paradigm shift away from using solvents in organic synthesis as solventle ss reactions can lead to improved outcomes, and more benign synthetic proce dures, in for example aldol condensation reactions, sequential aldol and Mi chael addition reactions en route to Krohnke type pyridines, reactions lead ing to 3-carboxycoumarins, benzylidenes, 4-aryl-1,4-dihydropyridines and 2- aryl-1,2,3,4-tetrahydroquinazolines, and oligomerisation reactions for the synthesis of cavitands; kinetic considerations for the reaction of two soli ds can only be explained if a eutectic melt is formed during the reaction.