Extreme (10(9)) acidification of adenine-NH2 in an open platinated nucleobase quartet. A pH switch with potential as a biological acid/base catalyst

Authors
Luth, MS Willermann, M Lippert, B
Citation
Ms. Luth et al., Extreme (10(9)) acidification of adenine-NH2 in an open platinated nucleobase quartet. A pH switch with potential as a biological acid/base catalyst, CHEM COMMUN, (20), 2001, pp. 2058-2059
Citations number
34
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
20
Year of publication
2001
Pages
2058 - 2059
Database
ISI
SICI code
1359-7345(2001):20<2058:E(AOAI>2.0.ZU;2-9
Abstract
The combination of electronic effects (Pt-II binding to N-7 and N-1) and a favourable conformation permitting efficient stabilization of the anion bri ngs about a 10(9) fold increase in the exocyclic amino group acidity of 9-e thyladenine.