Br. Babu et J. Wengel, Universal hybridization using LNA (locked nucleic acid) containing a novelpyrene LNA nucleotide monomer, CHEM COMMUN, (20), 2001, pp. 2114-2115
A novel pyrene LNA nucleotide monomer is shown to mediate universal hybridi
zation when incorporated into a DNA strand or a 2'-OMe-RNA/LNA chimeric str
and. For the latter, high-affinity universal hybridization without compromi
sing the base-pairing selectivity of bases neighbouring the universal pyren
e LNA nucleotide monomer is documented.