Universal hybridization using LNA (locked nucleic acid) containing a novelpyrene LNA nucleotide monomer

Authors
Babu, BR Wengel, J
Citation
Br. Babu et J. Wengel, Universal hybridization using LNA (locked nucleic acid) containing a novelpyrene LNA nucleotide monomer, CHEM COMMUN, (20), 2001, pp. 2114-2115
Citations number
17
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
20
Year of publication
2001
Pages
2114 - 2115
Database
ISI
SICI code
1359-7345(2001):20<2114:UHUL(N>2.0.ZU;2-D
Abstract
A novel pyrene LNA nucleotide monomer is shown to mediate universal hybridi zation when incorporated into a DNA strand or a 2'-OMe-RNA/LNA chimeric str and. For the latter, high-affinity universal hybridization without compromi sing the base-pairing selectivity of bases neighbouring the universal pyren e LNA nucleotide monomer is documented.