Biosynthesis of the vancomycin group of antibiotics: characterisation of atype III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine

Authors
Li, TL Choroba, OW Hong, H Williams, DH Spencer, JB
Citation
Tl. Li et al., Biosynthesis of the vancomycin group of antibiotics: characterisation of atype III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine, CHEM COMMUN, (20), 2001, pp. 2156-2157
Citations number
11
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
20
Year of publication
2001
Pages
2156 - 2157
Database
ISI
SICI code
1359-7345(2001):20<2156:BOTVGO>2.0.ZU;2-M
Abstract
3,5-dihydroxyphenylacetate, a precursor for the non-proteinogenic amino aci d 3,5-dihydroxyphenylglycine occurring in glycopeptide antibiotics, is dete rmined to be catalysed by a type III polyketide synthase using malonyl-CoA as a starter unit.