Comparative in vitro activities of five quinolone antibiotics, including gemifloxacin, against clinical isolates

Authors
Gonullu, N Aktas, Z Salcioglu, M Bal, C Ang, O
Citation
N. Gonullu et al., Comparative in vitro activities of five quinolone antibiotics, including gemifloxacin, against clinical isolates, CL MICRO IN, 7(9), 2001, pp. 499-503
Citations number
17
Categorie Soggetti
Clinical Immunolgy & Infectious Disease
Journal title
CLINICAL MICROBIOLOGY AND INFECTION
ISSN journal
1198743X → ACNP
Volume
7
Issue
9
Year of publication
2001
Pages
499 - 503
Database
ISI
SICI code
1198-743X(200109)7:9<499:CIVAOF>2.0.ZU;2-9
Abstract
The in vitro activities of ciprofloxacin, ofloxacin, norfloxacin, levofloxa cin and gemifloxacin against 343 clinical isolates were compared. Gemifloxa cin showed the greatest activity, with MIC90 values as low as 0.03-0.25 mg/ L against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catar rhalis, methicillin-susceptible Staphylococcus aureus and Klebsiella pneumo niae, while methicillin-resistant Staphylococcus aureus, Enterococcus spp., Pseudomonas spp., Acinetobacter spp., Escherichia coli and Enterobacter sp p. strains exhibited low rates of susceptibility to all five fluoroquinolon es.