N. Gonullu et al., Comparative in vitro activities of five quinolone antibiotics, including gemifloxacin, against clinical isolates, CL MICRO IN, 7(9), 2001, pp. 499-503
The in vitro activities of ciprofloxacin, ofloxacin, norfloxacin, levofloxa
cin and gemifloxacin against 343 clinical isolates were compared. Gemifloxa
cin showed the greatest activity, with MIC90 values as low as 0.03-0.25 mg/
L against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catar
rhalis, methicillin-susceptible Staphylococcus aureus and Klebsiella pneumo
niae, while methicillin-resistant Staphylococcus aureus, Enterococcus spp.,
Pseudomonas spp., Acinetobacter spp., Escherichia coli and Enterobacter sp
p. strains exhibited low rates of susceptibility to all five fluoroquinolon
es.