Separation of hydrophilic oligomers and polymers using monodisperse poly(2,3-dihydroxypropyl methacrylate-co-ethylene dimethacrylate) beads via normal-phase and hydrophilic-interaction HPLC

Authors
Svec, F Petro, M Frechet, JMJ
Citation
F. Svec et al., Separation of hydrophilic oligomers and polymers using monodisperse poly(2,3-dihydroxypropyl methacrylate-co-ethylene dimethacrylate) beads via normal-phase and hydrophilic-interaction HPLC, COLL CZECH, 66(7), 2001, pp. 1047-1061
Citations number
49
Categorie Soggetti
Chemistry
Journal title
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
ISSN journal
00100765 → ACNP
Volume
66
Issue
7
Year of publication
2001
Pages
1047 - 1061
Database
ISI
SICI code
0010-0765(200107)66:7<1047:SOHOAP>2.0.ZU;2-X
Abstract
Microparticulate, monosized, and macroporous poly(2,3-dihydroxypropyl metha crylate-co-ethylene dimethacrylate) beads have been used as a stationary ph ase for HPLC separations of hydrophilic oligomers and polymers. Homogeneous coverage of the sorbent surface with a large number of chemically equivale nt diol functionalities affords suitable retentivity in both normal-phase a nd hydrophilic-interaction chromatographic modes and enables the separation s of water-soluble oligomers and polymers. Chromatographic properties of th is stationary phase are demonstrated on a variety of separations of poly(ox yalkylene)s, polyvinylpyrrolidones, and polysaccharides.