T-cell subpopulations contact allergy

Remarkable progress has been made in our understanding of the pathogenesis of skin diseases mediated by T cells. T-cell subsets responsible for the ex pression and regulation of allergic contact dermatitis to small chemicals o r 'haptens' have been defined further, and the dynamics of T cells involved in the pathogenesis of atopic dermatitis have been clarified. In addition, studies are beginning to reveal the important contribution of skin residen t cells to atopic dermatitis and the underlying molecular mechanisms.