Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens

Authors
McKenzie, GJ Rosenberg, SM
Citation
Gj. Mckenzie et Sm. Rosenberg, Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens, CURR OPIN M, 4(5), 2001, pp. 586-594
Citations number
79
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
CURRENT OPINION IN MICROBIOLOGY
ISSN journal
13695274 → ACNP
Volume
4
Issue
5
Year of publication
2001
Pages
586 - 594
Database
ISI
SICI code
1369-5274(200110)4:5<586:AMMDPA>2.0.ZU;2-H
Abstract
'Adaptive' or 'stationary-phase' mutation is a collection of stress respons es promoting mutations, some of which are advantageous. In 2000 and 2001, i n Escherichia coli, adaptive gene amplification was documented, and a paral lel adaptive point-mutation mechanism was linked to the error-prone DNA pol ymerase, DinB (pol IV). We suggest that DinB homologues may contribute to a daptive strategies of pathogens, including antigenic variation.