Serum levels of advanced glycation end products in poorly metabolically controlled children with diabetes mellitus: Relation to HbA(1c)

Serum levels of advanced glycation end products (s-AGEs) were investigated in children with poorly metabolically controlled diabetes to determine whet her they may be correlated with HbA(1c), fructosamine, glycaemia, albumin e xcretion rate, duration of diabetes and age. In this study, 17 children wit h Type I diabetes mellitus (age range 9 to 18 yr) and 8 healthy children (a ge range 7 to 17 yr) served as subjects. S-AGEs were found to be increased in poorly metabolically controlled children with diabetes (HbA(1c)>9%). A s ignificant correlation (r=0.65; p <0.01) was found between s-AGEs and HbA(1 c) in the group of diabetic children. In poorly metabolically controlled ch ildren with diabetes of pre-pubertal and pubertal age, the level of s-AGEs should be monitored as the risk of microvascular complications may be alrea dy present at this early stage of life. (C) 2001, Editrice Kurds.