Irresistible IRES - Attracting the translation machinery to internal ribosome entry sites

Authors
Vagner, S Galy, B Pyronnet, S
Citation
S. Vagner et al., Irresistible IRES - Attracting the translation machinery to internal ribosome entry sites, EMBO REP, 2(10), 2001, pp. 893-898
Citations number
53
Categorie Soggetti
Molecular Biology & Genetics
Journal title
EMBO REPORTS
ISSN journal
1469221X → ACNP
Volume
2
Issue
10
Year of publication
2001
Pages
893 - 898
Database
ISI
SICI code
1469-221X(200110)2:10<893:II-ATT>2.0.ZU;2-#
Abstract
Studies on the control of eukaryotic translation initiation by a cap-indepe ndent recruitment of the 40S ribosomal subunit to internal messenger RNA se quences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.