A 15-year-old male with hypereosinophilic syndrome was admitted to our
hospital because of general malaise and abnormal liver function tests
. Endoscopic retrograde cholangiopancreatography demonstrated bile duc
t changes consistent with primary sclerosing cholangitis. The patient'
s liver profile tests returned to normal after treatment with predniso
lone and ursodeoxycholic acid. In this case, eosinophils might have pl
ayed an important role in the pathogenesis of the bile duct lesion.