DIABETIC LIPEMIA WITH MATURITY-ONSET DIABETES OF THE YOUNG

A 19-year-old woman with diabetic lipemia and maturity-onset diabetes of the young (MODY) is reported. Though her insulin secretory activity was preserved, she fell into mild diabetic ketoacidosis (DKA) and sho wed type V hyperlipidemia. Post-heparin plasma activity of lipoprotein lipase (LPL) was decreased even 10 days after initiating insulin inje ction but not deficient. The abnormalities in lipid metabolism were im proved by long-term insulin treatment. Though the contribution of the genetic background to the lipid abnormalities is not clear, the charac teristics of MODY in this patient including insulin secretory capacity under stress conditions such as DKA might play a role in the developm ent of diabetic lipemia.