IMMEDIATE-TYPE HUMAN INSULIN ALLERGY SUCCESSFULLY TREATED BY CONTINUOUS SUBCUTANEOUS INSULIN INFUSION

A 63-year-old insulin-dependent diabetic woman was hospitalized with i tchy skin wheals at the injection sites of human insulin. After intrad ermal skin testing was performed, the erythema and wheal was recorded immediately. The increased titer of human insulin-specific IgE antibod y indicated immediate-type allergy against human insulin. Administrati on of an anti-allergic drug or desensitization for human insulin every 2 hours was not effective, After continuous subcutaneous insulin infu sion (CSII) therapy was performed, both the itching and wheal disappea red. The process may be a desensitization through CSII. CSII may be us eful in the treatment for human insulin allergy.