Drug-induced nonconvulsive status epilepticus with low dose of tiagabine

In placebo-controlled trials, the overall incidence of nonconvulsive status epilepticus was no higher in the tiagabine-treated group than in the place bo-group. Case reports of nonconvulsive status epilepticus under tiagabine suggested a specific role of dose levels, since in these patients symptoms occurred mostly at 40 mg/day or higher. We report a case of complex partial status epilepticus in a patient receiving a low dose of tiagabine and revi ew all 11 case reports of nonconvulsive status epilepticus in patients on t iagabine, with regard to daily doses. Our analysis suggests an individual r isk threshold of unknown aetiology.