Described here is a case of Aspergillus fumigatus cranial infection seconda
ry to accidental cranial traumatism that occurred in an immunocompetent pat
ient and the questions that arose concerning treatment. No reports of post-
traumatic cranial osteomyelitis caused by Aspergillus spp. and the ideal tr
eatment to be followed have yet been described in the literature. In the pr
esent case, surgical debridement of the wound followed by treatment with I
mg/kg/iv/day of amphotericin B for 21 days and then 200 mg/vo/12 h of itrac
onazole for 6 months obtained good results.