Quantitative phalangeal bone ultrasound is normal after long-term gluten-free diet in young coeliac patients

Background and aims To determine bone mass using quantitative phalangeal bo ne ultrasound in young coeliac patients after a long-term gluten-free diet. Subjects A total of 99 patients with coeliac disease (CD) (52 girls, mean a ge 15.5 +/- 9.7 years; 47 boys, mean age 14.4 +/- 8.4 years) and 44 healthy subjects matched for age, weight and height (26 girls, mean age 18.4 +/- 9 .9 years; 18 boys, mean age 16.3 +/- 11.2 years) were included in the study . Methods Bone status was assessed using an ultrasound device that measures a mplitude-dependent speed of sound (Ad-SoS) in metres per second. Measuremen ts were made on the phalanges (II-V) of the non-dominant hand, and an avera ge value was computed. Nutrient intake was assessed using a 7-day record. Results Analysis of variance (ANOVA) and the unpaired t-test showed that th e intake of phosphates (P < 0.05), proteins, fat and carbohydrates (P < 0.0 05 in all) was higher in patients than in controls. No significant differen ce in Ad-SoS was found between patients and controls (95% CI -10.9 to 60.6) in the overall group, in girls or boys, or in patients following a gluten- free diet strictly or partially. In the patients, only age (beta 4.01, 95% CI 1.84-6.16, P < 0.0005) and weight (<beta> 2.62, 95% CI 1.53-3.70, P < 0. 0001) showed a significant positive relation with Ad-SoS. Conclusions In patients with CD, gluten-free diet and increased nutritional intake were accompanied by normal bone mass values as determined by ultras ound on phalanges. Eur J Gastroenterol Hepatol 13:1169-1173 (C) 2001 Lippin cott Williams & Wilkins.