AM630 IS A COMPETITIVE CANNABINOID RECEPTOR ANTAGONIST IN THE GUINEA-PIG BRAIN

AM630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reporte d that AM630 acts as a cannabinoid agonist in the guinea pig ileum. Th is research was designed to determine whether the difference in the ac tion of AM630 is species specific. Studies conducted in guinea pig bra in reveal that AM630 antagonizes the stimulatory effect of the cannabi noid agonist WIN 55,212-2 on [S-35]GTP gamma S binding suggesting that difference in AM630 activity in different tissues is not due to speci es (C) 1997 Elsevier Science Inc.