Follicular dendritic cells (FDC) constitute an essential component of B cel
l follicles, normally serving as antigen-p resenting cells and as cells reg
ulating the germinal center reaction. FDC sarcoma is a very rare tumor. We
report the case of a 55-year-old male patient who showed persistent cervica
l lymph node swelling. On biopsy the tumor consisted of spindle cells with
nuclear atypia. Immunophenotypic investigation of the tumor tissue revealed
a FDC sarcoma of a cervical lymph node. The tumor cells were characterized
immunohistochemically especially by the expression of CD21 and focal expre
ssion of CD68.
In conclusion, FDC sarcoma has to be considered in cases of tumors of uncer
tain origin in cervical lymph nodes,tonsils, soft palate, or nasopharynx. F
or clinical practice, it is important to note that sarcomas in cervical lym
ph nodes are not necessarily metastases but can be primary tumors.