The birth and death of human single-nucleotide polymorphisms: new experimental evidence and implications for human history and medicine

Authors
Miller, RD Kwok, PY
Citation
Rd. Miller et Py. Kwok, The birth and death of human single-nucleotide polymorphisms: new experimental evidence and implications for human history and medicine, HUM MOL GEN, 10(20), 2001, pp. 2195-2198
Citations number
32
Categorie Soggetti
Molecular Biology & Genetics
Journal title
HUMAN MOLECULAR GENETICS
ISSN journal
09646906 → ACNP
Volume
10
Issue
20
Year of publication
2001
Pages
2195 - 2198
Database
ISI
SICI code
0964-6906(20011001)10:20<2195:TBADOH>2.0.ZU;2-5
Abstract
Extensive, new databases of single-nucleotide polymorphisms (SNPs) provide a powerful resource for disease gene discovery, and they will be even more useful as more frequency data become available. Interesting observed genomi c, patterns include SNP deserts (regions of low SNP incidence) and lengthy regions of linkage disequilibrium containing only a few haplotypes. A varie ty of genetic studies will benefit from SNP resources.