Modeling the reactivity of superoxide reducing metalloenzymes with a nitrogen and sulfur coordinated iron complex

Authors
Shearer, J Nehring, J Lovell, S Kaminsky, W Kovacs, JA
Citation
J. Shearer et al., Modeling the reactivity of superoxide reducing metalloenzymes with a nitrogen and sulfur coordinated iron complex, INORG CHEM, 40(22), 2001, pp. 5483
Citations number
16
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANIC CHEMISTRY
ISSN journal
00201669 → ACNP
Volume
40
Issue
22
Year of publication
2001
Database
ISI
SICI code
0020-1669(20011022)40:22<5483:MTROSR>2.0.ZU;2-Z
Abstract
The synthesis and structure of a five-coordinate Fe(II) complex, [(FeSN4)-S -II-N-Me2 (tren)](PF6) (1), which models the reactive properties of superox ide reductases (SORs), is reported. SORs catalyze the reduction of superoxi de to peroxide in anaerobic organisms, thereby avoiding the O-2 formed in t he more typical superoxide degradation enzyme superoxide dismutase (SOD). T he thiolate ligand contained in model 1, as well as in SORs appears to play an important role in promoting SOR activity.