Insertion polymorphism of CYP2EI and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers

Objectives: This study examined whether consideration of the *1C/*1D CY-P2E 1 insertion polymorphism is important for interpreting the biological monit oring of exposure to NN-dimethylformamide (DMF) in Japanese workers. Method s: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week we re determined in 44 male and female Japanese workers. Results and conclusio ns. The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Jap anese population of workers. The CYP2E1 insertion polymorphism did not cont ribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to D MF by the measurement of urinary NMF.