Compared to the past, caries removal has become more efficient, however inh
erent fundamental drawbacks of the drilling approach have remained: unpleas
antness to patients, need for local anesthesia, and potential adverse effec
ts to the pulp due to heat and pressure. Chemomechanical caries removal, in
troduced almost three decades ago, was claimed to be a non-invasive alterna
tive for the removal of carious dentine. In essence, the technique involved
applying a solution onto the decayed dentinal tissue, allowing it to softe
n it, and, finally, scraping it off with blunt hand instruments. The partia
lly degraded collagen in carious dentine was chlorinated by chemomechanical
caries removal solutions. This chlorination affected the secondary and/or
quaternary structure of collagen, by disrupting hydrogen bonding. Carious m
aterial removal was thus facilitated. The purpose of this paper is to perfo
rm a comprehensive review of the literature regarding chemomechanical carie
s removal, including the most recently available product, the initial repor
ts on which warrant renewed interest in the approach.