Involvement of angiogenesis in weight-loss in tumor-bearing and diet-restricted animals

The body's weight loss mechanism while in a tumor-bearing state is still un clear. In this study, we investigated expressions of angiogenic factors in the adipose tissue of tumor-bearing and diet-restricted rabbits evaluating the differences between the two groups. We postulated that low nutrition in duced vasculogenesis to transport nutrition in the adipose tissues of diet- restricted rabbits, unlike in tumor-bearing rabbits, and that vascular endo thelial growth factor (VEGF) and platelet-derived endothelial cell growth f actor (PD-ECGF) were related to angiogenesis of the adipose tissues. Althou gh we investigated the expressions of VEGF and PD-ECGF immunohistochemicall y in tumor-bearing and diet-restricted rabbits, there was no significant di fference between the two groups. Whether angiogenesis of the adipose tissue in the diet-restricted animals may be observed during the nutritional reco very period should be investigated.