YUA001, a novel aldose reductase inhibitor isolated from alkalophilic Corynebacterium sp. YUA25 - II. Chemical modification and biological activity

Authors
Sun, WS Lee, HS Park, JM Kim, SH Yu, JH Kim, JH
Citation
Ws. Sun et al., YUA001, a novel aldose reductase inhibitor isolated from alkalophilic Corynebacterium sp. YUA25 - II. Chemical modification and biological activity, J ANTIBIOT, 54(10), 2001, pp. 827-830
Citations number
10
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
54
Issue
10
Year of publication
2001
Pages
827 - 830
Database
ISI
SICI code
0021-8820(200110)54:10<827:YANARI>2.0.ZU;2-Y
Abstract
A series of novel N-substituted tyramine (2-p-hydroxyphenylethylamine) deri vatives (1 similar to 11) were synthesized and evaluated for their inhibito ry activity against pig kidney aldose reductase (EC 1, 1, 1, 21). Of these compounds, N-2-p-hydroxyphenylethyl maleamic acid (10) exhibits the stronge st aldose reductase inhibitory activity, which is 22 times more potent than that of YUA001(1)).