Effects of mullerian anomalies on in vitro fertilization outcome

Purpose. To assess the effect of Mullerian anomalies on pregnancy rates in women undergoing in vitro fertilization (IVF). Methods. The records of 37 patients with and 819 patients without Mullerian anomalies undergoing a first cycle of IVF between December 1995 and July 1 998 were included in this retrospective study. Outcome variables included m aximal estradiol level, number of days of stimulation, number of follicles, number of oocytes, fertilization rate, and ongoing/livebirth pregnancy rat e. Results. Patients with Mullerian anomalies had a significantly lower ongoin g pregnancy rate (8.3%) than did controls (24.8%). No patients with diethyl stilbestrol (DES)related anomalies had an ongoing pregnancy. Conclusions: Among women with Mullerian anomalies, those with DES exposure in utero demonstrated the poorest outcome.