A 6-month-old foal was evaluated because of weakness, weight loss, and
inappetence of 3 weeks' duration. On initial examination, the foal wa
s weak, poorly responsive, and emaciated. Clinicopathologic abnormalit
ies included anemia and hypoproteinemia. Because of its severe debilit
ation, the foal was euthanatized. Necropsy revealed marked infection o
f the small intestine with Strongyloides westeri and severe edema of t
he entire gastrointestinal tract. The foal had been orphaned when it w
as 6 hours old and raised in isolation from other horses. We believe t
hat this foal developed overwhelming strongyloidosis when it was first
exposed to other foals at 5 months of age, because it had not been na
turally exposed to the organism at a younger age and was immunological
ly naive.