Focal nodular hyperplasia of the liver after intraconazole treatment

Citation
R. Wolf et al., Focal nodular hyperplasia of the liver after intraconazole treatment, J CLIN GAST, 33(5), 2001, pp. 418-420
Citations number
59
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
JOURNAL OF CLINICAL GASTROENTEROLOGY
ISSN journal
01920790 → ACNP
Volume
33
Issue
5
Year of publication
2001
Pages
418 - 420
Database
ISI
SICI code
0192-0790(200111/12)33:5<418:FNHOTL>2.0.ZU;2-Q
Abstract
A 38-year-old woman developed focal nodular hyperplasia of the liver after she had received a 4-month treatment with intraconazole 200 mg/d for a fung al infection of her fingernails. Because the patient underwent yearly liver ultrasound examinations because of the removal of a breast carcinoma, when the tumor was discovered incidentally, it was clear that it had developed within the past year after she had begun receiving intraconazole. Although various chemical agents and drugs have been considered as possible etiologi c factors in the development of focal nodular hyperplasia of the liver. cas es occurring after intraconazole therapy have not been reported before. Apa rt from the theoretical considerations with regard to the pathogenesis of n odular hyperplasia of the liver, this case could gain practical importance, as it shows a new adverse effect of a drug that has been used in more than 34 million patients over the past 10 years. Furthermore, this case should draw attention to the possibility of drug-induced benign hepatic tumors, as they may mimic malignant and metastatic disorders, which might be especial ly alarming in patients undergoing routine examinations after removal of ma lignant tumors, such as our patient.