This study evaluated the effect of the fifth-generation dentin adhesives, S
ingle Bond (SB), Excite (EX), Prime & Bond NT (PB), and Optibond Solo (OS)
on nerve conduction. Isolated rat sciatic nerves were placed between two su
ction electrodes in a bath containing tyrode solution. The bonding agents w
ere brought into contact with the nerves and the evoked compound action pot
entials (cAPs) were recorded before and after contact with the materials. S
B, EX, and PB caused total inhibition of the cAPs, with PB being the fastes
t (73 +/-5.8 min). All cAPs except one in the PB group were irreversibly in
hibited in the SB, EX, and PB groups. As for OS the reduction in cAP was no
t 50% after an application time of 200 min. Recovery of the cAPs in this gr
oup was recorded in an average time of 35 min.