Microbial synthesis of a deuterium-labelled metabolite of an NK1 receptor antagonist, TAK-637

Authors
Tarui, N Ikeura, Y Natsugari, H Nakahama, K
Citation
N. Tarui et al., Microbial synthesis of a deuterium-labelled metabolite of an NK1 receptor antagonist, TAK-637, J LABEL C R, 44(12), 2001, pp. 865-870
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
44
Issue
12
Year of publication
2001
Pages
865 - 870
Database
ISI
SICI code
0362-4803(20011030)44:12<865:MSOADM>2.0.ZU;2-S
Abstract
Microbial conversion of deuterium-labelled TAK-637 ((aR,9S)-[10,10,11, 11-H -2(4)]-7-[3,5-bis(trifluoromethyl)benzyl]-8,9,10,11-tetrahydro-9-methyl-5-( 4-methylphenyl)-7H-[1,4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione, 1) w as carried out using Streptomyces subrutilus IFO13388 to give a deuterium-l abelled hydroxylated TAK-637 ((aR,9S)- [10,10,11,11-H-2(4)]-7-[3,5-bis(trif luoromethyl)benzyl]-8,9,10,11-tetraliydro-9-methyl-5-(4-hydroxymethylphenyl )-7H-[1.4]diazocino[2,1-g][1,7]naphthyridine-6,13-dione, 2) for use as an i nternal standard in LC-MS studies. Copyright (C) 2001 John Wiley & Sons, Lt d.