Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin

Authors
Langlois, N Rojas-Rousseau, A Gaspard, C Werner, GH Darro, F Kiss, R
Citation
N. Langlois et al., Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin, J MED CHEM, 44(22), 2001, pp. 3754-3757
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
00222623 → ACNP
Volume
44
Issue
22
Year of publication
2001
Pages
3754 - 3757
Database
ISI
SICI code
0022-2623(20011025)44:22<3754:SACOSA>2.0.ZU;2-B
Abstract
A new 7,8-methylenedioxy analogue (4) of (+)-porothramycin B (2) and its wa ter-soluble sodium bisulfite derivative (15) have been synthesized in high yields and have been shown to exhibit high cytotoxic activities against sev eral tumor cell lines. The new pyrrolo [2, 1-c] [1,4] benzodiazepine 4 was as effective against the resistant cell lines as against the doxorubicin-se nsitive cell lines tested.