Medium-dose UVA1 phototherapy in localized scleroderma and its effect in CD34-positive dendritic cells

Background. UVA1 radiation seems to be effective in morphea. CD34(+) dendri tic cells are significantly decreased in lesional skin of morphea patients. Objective: We evaluated the therapeutic effectiveness of medium-close UVA1 phototherapy, in localized scleroderma and its effect in the number of derm al CD34(+) dendritic cells in skin biopsy specimens of these patients. Method: Patients were irradiated with UVA1 (30 J/cm(2)) 30 times. Dermal CD 34(+) dendritic cells were counted before and after therapy. Results: There was clinical improvement after UVA1 irradiation. Dermal CD34 (+) dendritic cells significantly increased after UVA1 irradiation. Conclusion: Medium-close UVA1 therapy is effective in the treatment of loca lized morphea, Effectiveness is associated with an increase in the number o f CD34(+) dendritic cells in the dermis.