L. Anastasia et al., A practical protocol for the synthesis of 3-hydroxy-4,5-disubstituted pyridine derivatives from acyclic compounds, J CHEM S P1, (19), 2001, pp. 2404-2408
The paper reports a simple protocol for assembling a 3-hydroxy-4,5-disubsti
tuted pyridine ring by reaction of allylamine or benzylamine and an alpha -
bromo ketone and successive N-dealkylation.