This analysis examines the complexity of adolescent health risk behaviors u
sing data from the National Longitudinal Study of Adolescent Health (Add He
alth), a nationally representative study of students. The Current sample in
cludes 12,955 students (6,626 females and 6,329 males) in grades 9 through
12. Cluster analysis was conducted separately by gender to examine the inte
rrelationships among eight health risk behaviors: sexual activity, general
alcohol use, binge drinking, cigarette use, marijuana use, other illicit dr
ug use, fighting, and suicide. Four distinct clusters for females and males
were identified based on their profiles of risk-taking behavior Females an
d males both report low- and high-risk profiles, and a risk profile with hi
gh alcohol use and sexual activity. Females have two distinct risk profiles
, one that is highest on every measure of risk compared to others and one t
hat has high levels of fighting and suicide with little participation in su
bstance use or sexual activity Males have a distinct risk profile with part
icularly high rates of marijuana use and suicidal behaviors. Few distinctio
ns exist between profiles based on sociodemographic characteristics.