Lithium affects the reactivities of GalNAc alpha 1-3GalNAc-lipid and fibrinopeptide A in mice

Authors
Masuda, Y Sugawara, J Kawarada, Y Sugiyama, T
Citation
Y. Masuda et al., Lithium affects the reactivities of GalNAc alpha 1-3GalNAc-lipid and fibrinopeptide A in mice, METH FIND E, 23(5), 2001, pp. 219-221
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
ISSN journal
03790355 → ACNP
Volume
23
Issue
5
Year of publication
2001
Pages
219 - 221
Database
ISI
SICI code
0379-0355(200106)23:5<219:LATROG>2.0.ZU;2-B
Abstract
The relationship between lithium and the reactivities of GalNAc alpha1-3Gal NAc-lipid and fibrinopeptide A were investigated in mice. Lithium strongly decreased glycolipid reactivity and slightly increased peptide reactivity i n a dose- and time-dependent manner. These substances showed antidepressive behavioral effects in mice via different neurological activities. This may suggest a mechanism of two different clinical effects of lithium: One of w hich is a strong antimanic effect and one of which is a weak antidepressive effect. (C) 2001 Prous Science. All rights reserved.