Significance of the catechol-O-methyltransferase gene polymorphism in migraine

The objective was to assess the significance of the catechol-o-methyltransf erase (COMT) enzyme polymorphism in migraine. For this reason, 62 migraineu rs and 64 healthy volunteers were included in the study. The analysis of CO MT polymorphism was performed using PCR. The H/H genotype was more frequent in the control group than in the patients group (P = 0.032). The homozygou s or heterozygous L allele was over represented in the migraineurs compared with the controls (P = 0.013). The L/L genotype was over represented in th e migraineurs who also had a family history of migraine (P = 0.003). There was no relationship between aura and COMT genotypes. In conclusion, the COM T polymorphism may be of potential pharmacological importance regarding the individual differences in the metabolism of catechol drugs in migraineurs. Although altered catechoamine activity due to polymorphism of COMT gene ma y be one of the mechanisms involved in the pathogenesis of migraine, these mechanisms are not related to presence or absence of aura. (C) 2001 Elsevie r Science BY All rights reserved.