Management of hyperinsulinemia with diazoxide in an elderly hemodialysis patient

An elderly, nondiabetic, chronic hemodialysis patient is described here who had profound hypoglycemia for a myriad of reasons including renal failure, malnutrition, and quinine use. Furthermore, by biochemical parameters the patient had hyperinsulinemia, which was consistent with the diagnosis of an insulinoma. However, a tumor was not identified by noninvasive radiologic imaging as is often the case and the patient was not a candidate for surgic al exploration. Diazoxide at a dose of 225 mg/day was used to successfully manage this patient's hypoglycemia. Previous experience with the use of dia zoxicle for hyperinsulinism in the hemodialysis population is limited and t his case is the second report of its use for this purpose. Copyright (C) 20 01 S. Karger AG, Basel.