A formalism for calculating the open supermembrane contribution to the nonp
erturbative superpotential of moduli in heterotic M-theory is presented. Th
is is explicitly applied to the Calabi-Yau (1, 1)-moduli and the separation
modulus of the end-of-the-world BPS three-branes, whose nonperturbative su
perpotential is computed. The role of gauge bundles on the boundaries of th
e open supermembranes is discussed in detail, and a topological criterion p
resented for the associated superpotential to be nonvanishing. (C) 2001 Pub
lished by Elsevier Science B.V.