In this work we update the constraints on tree level FCNC couplings in the
framework of a theory with n isosinglet vector-like down quarks. In this co
ntext, we emphasize the sensitivity of the B J/psi K-S CP asymmetry to the
presence of new vector-like down quarks. This CP asymmetry, together with t
he rare decays B --> X(s,d)l (l) over bar and K --> pi nu<(<nu>)over bar> a
re the best options to further constrain the FCNC tree level couplings or e
ven to point out, in the near future, the possible presence of vector-like
quarks in the low energy spectrum, as suggested by GUT theories or models o
f large extra dimensions at the TeV scale. (C) 2001 Elsevier Science B.V. A
ll rights reserved.