The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus

Authors
Ratnayake, AS Yoshida, WY Mooberry, SL Hemscheidt, T
Citation
As. Ratnayake et al., The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus, ORG LETT, 3(22), 2001, pp. 3479-3481
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
22
Year of publication
2001
Pages
3479 - 3481
Database
ISI
SICI code
1523-7060(20011101)3:22<3479:TSOMAM>2.0.ZU;2-N
Abstract
[GRAPHICS] A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated fro m fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupti ng agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chiralit y method.