L. Tedeschi et D. Enders, Asymmetric synthesis of beta-phosphono malonates via Fe2O3-mediated phospha-Michael addition to knoevenagel acceptors, ORG LETT, 3(22), 2001, pp. 3515-3517
[GRAPHICS]
The first asymmetric P-C bond formation under heterogeneous conditions was
achieved via a Fe2O3-mediated conjugate addition of a chiral phosphite to a
lkylidene malonates. The easy cleavage of the chiral auxiliary from the add
ition products leads to optically active beta -substituted, beta -phosphono
malonates in good yields and high enantiomeric excesses.