Palladium-mediated regiodivergent kinetic resolution

Authors
Cook, GR Sankaranarayanan, S
Citation
Gr. Cook et S. Sankaranarayanan, Palladium-mediated regiodivergent kinetic resolution, ORG LETT, 3(22), 2001, pp. 3531-3533
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
22
Year of publication
2001
Pages
3531 - 3533
Database
ISI
SICI code
1523-7060(20011101)3:22<3531:PRKR>2.0.ZU;2-3
Abstract
[GRAPHICS] The allylic substitution of racemic 5-vinyloxazolidinones with phthalimide and a chiral palladium catalyst afforded optically enriched regioisomeric p roducts. Optimal divergence was found by employing chiral DIOP ligands in t oluene. These results demonstrate the influence of chiral ligand/chiral sub strate matching on the regloselectivity in a novel resolution strategy.