A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)

Authors
Zheng, YJ Huo, Q Kele, P Andreopoulos, FM Pham, SM Leblanc, RM
Citation
Yj. Zheng et al., A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK), ORG LETT, 3(21), 2001, pp. 3277-3280
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
21
Year of publication
2001
Pages
3277 - 3280
Database
ISI
SICI code
1523-7060(20011018)3:21<3277:ANFCFC>2.0.ZU;2-8
Abstract
[GRAPHICS] A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying th e tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluo rescence quenching was observed from the molecule upon binding with Cu2+, a ddition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a mini mum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.