Nickel-promoted alkylative or arylative carboxylation of alkynes

Authors
Takimoto, M Shimizu, K Mori, M
Citation
M. Takimoto et al., Nickel-promoted alkylative or arylative carboxylation of alkynes, ORG LETT, 3(21), 2001, pp. 3345-3347
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
21
Year of publication
2001
Pages
3345 - 3347
Database
ISI
SICI code
1523-7060(20011018)3:21<3345:NAOACO>2.0.ZU;2-8
Abstract
[GRAPHICS] Nickel-promoted alkylative or arylative carboxylation of terminal alkynes v ia a carbon dioxide fixation process was investigated. In the presence of a stoichiometric amount of a zero-valent nickel complex, the reaction of alk ynes with CO2 gave a nickelacycle, which was reacted with various organozin c reagents under very mild conditions to provide beta,beta'-disubstituted, alpha,beta -unsaturated carboxylic acids in a highly regio- and stereoselec tive manner.