Facile enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(1H)-pyridones.First total synthesis of both enantiomers of pipermethystine

Authors
Arrayas, RG Alcudia, A Liebeskind, LS
Citation
Rg. Arrayas et al., Facile enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(1H)-pyridones.First total synthesis of both enantiomers of pipermethystine, ORG LETT, 3(21), 2001, pp. 3381-3383
Citations number
43
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
21
Year of publication
2001
Pages
3381 - 3383
Database
ISI
SICI code
1523-7060(20011018)3:21<3381:FEAT5>2.0.ZU;2-E
Abstract
[GRAPHICS] A novel enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(lh)-pyridones using a ring closing metathesis and a lipase-mediated kinetic resolution as key steps is described and applied to the first synthesis of both enantiom ers of pipermethystine.