MOLECULAR CYTOGENETICS OF PROSTATE-CANCER

Prostate cancer is the most common malignancy among men in many develo ped countries. One-fourth of prostate cancers are diagnosed at metasta tic stage but there is no curative treatment for such disease and pall iative androgen withdrawal therapy remains the most used one. Thus, un derstanding the molecular events that underlie the development and pro gression of prostate cancer could help to answer many clinical questio ns on its treatment. In this review article, I want to illustrate some of the most interesting findings (by fluorescence in situ hybridizati on and comparative genomic hybridization) in the molecular cytogenetic s of prostate cancer.