AZT MONOPHOSPHATE KNOCKS THYMIDYLATE KINASE FOR A LOOP

Authors
KENYON GL
Citation
Gl. Kenyon, AZT MONOPHOSPHATE KNOCKS THYMIDYLATE KINASE FOR A LOOP, Nature structural biology, 4(8), 1997, pp. 595-597
Citations number
7
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
4
Issue
8
Year of publication
1997
Pages
595 - 597
Database
ISI
SICI code
1072-8368(1997)4:8<595:AMKTKF>2.0.ZU;2-L
Abstract
Structural and kinetic evidence points to an induced loop movement in thymidylate kinase as leading to the limiting step in AZT activation i n HIV therapy.